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M94A2363.TXT
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1994-10-25
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Document 2363
DOCN M94A2363
TI Interleukin 6 and AIDS Kaposi's sarcoma.
DT 9412
AU Dourado I; Detels R; Martinez-Maza O; UCLA School of Public Health.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):321 (abstract no. PC0213). Unique
Identifier : AIDSLINE ICA10/94370212
AB Since the beginning of the AIDS epidemic, a large research activity has
focused on the etiology of Kaposi's sarcoma (KS) among HIV infected
individuals. There are several hypothesized risk factors for AIDS-KS.
However, there is not enough evidence supporting the existing
hypotheses. Recently, a number of studies have confirmed that HIV or HIV
encoded products can interact with human cells to produce immune
cytokines. One of these cytokines is known as interleukin 6 (IL-6). In
vitro observations have indicated that AIDS-KS cells can produce and
respond to significant levels of IL-6. In addition, preliminary data
suggest that IL-6 may be elevated among HIV infected individuals that
subsequently develop AIDS-KS. The objective of this study was to
investigate if elevated levels of IL-6 are associated with an increased
incidence of AIDS-KS compared to other AIDS-defining illnesses such as
opportunistic infections (OIS). The specimens were frozen sera from the
participants of the Multicenter AIDS Cohort Study (MACS). IL-6 was
measured with an ELISA assay at 6 months prior to the AIDS diagnosis for
73 cases (AIDS-KS) and 152 controls (OIS). We found that IL-6 levels
were more prevalent among OIS than among AIDS-KS: crude odds ratio (OR)
was 0.4 (95% CI 0.2-0.9). Models of multivariate logistic regression
were used to study potential confounders. Sexual behavior variables did
not seem to be confounders of the association between IL-6 and AIDS-KS.
The higher prevalence of IL-6 among controls could be explained by the
association of higher levels of IL-6 with lower levels of CD4 T cell
number. IL-6 might be a marker of immunedysfunction among HIV infected
individuals.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY/
METABOLISM AIDS-Related Opportunistic Infections/METABOLISM Cohort
Studies Enzyme-Linked Immunosorbent Assay Human
Interleukin-6/*BIOSYNTHESIS Sarcoma, Kaposi's/ETIOLOGY/*METABOLISM
MEETING ABSTRACT MULTICENTER STUDY
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).